The Anterior Pituitary (Adenohypophysis) is a classical gland composed predominantly of cells that secrete protein hormones. The Posterior Pituitary (neurohypophysis) is not really an organ, but an extension of the hypothalamus. It is composed largely of the axons of hypothalamic neurons which extend downward as a large bundle behind the anterior pituitary. It also forms the so-called Pituitary Stalk - which appears to suspend the anterior gland from the hypothalamus The image on the right shows a frontal view of a sheep pituitary gland and hypothalamus. The posterior gland can be seen peeking out behind the anterior gland. The anterior and posterior pituitary have separate embryological origins. In many mammals, there is also an intermediate lobe (pars intermedia) between the anterior and posterior pituitary.

A key to understanding the endocrine relationship between hypothalamus and anterior pituitary is to appreciate the vascular connections between these organs. As will be emphasized a little later, secretion of hormones from the anterior pituitary is under strict control by hypothalamic hormones. These hypothalamic hormones reach the anterior pituitary through the following route:

• A branch of the hypophyseal artery ramifies into a capillary bed in the lower hypothalamus, and hypothalmic hormones destined for the anterior pituitary are secreted into that capillary blood.

• Blood from those capillaries drains into hypothalamic-hypophyseal portal veins. Portal veins are defined as veins between two capillary beds; the hypothalamic-hypophyseal portal veins branch again into another series of capillaries within the anterior pituitary.

• Capillaries within the anterior pituitary, which carry hormones secreted by that gland, coalesce into veins that drain into the systemic venous blood. Those veins also collect capillary blood from the posterior pituitary gland.

This pattern of vascular connections is presented in the diagram below. Note also the hypothalamic-hypophyseal portal vessels in the image of a real pituitary gland seen above.

The utility of this unconventional vascular system is that minute quantities of hypothalamic hormones are carried in a concentrated form directly to their target cells in the anterior pituitary, and are not diluted out in the systemic circulation.

Overview of Hypothalamic and Pituitary Hormones

The pituitary gland is often portrayed as the "master gland" of the body. Such praise is justified in the sense that the anterior and posterior pituitary secrete a battery of hormones that collectively influence all cells and affect virtually all physiologic processes.

The pituitary gland may be king, but the power behind the throne is clearly the hypothalamus. As aforementioned, some of the neurons within the hypothalamus - neurosecretory neurons - secrete hormones that strictly control secretion of hormones from the anterior pituitary. The hypothalamic hormones are referred to as releasing hormones and inhibiting hormones, reflecting their influence on anterior pituitary hormones. Hypothalamic releasing and inhibiting hormones are carried directly to the anterior pituitary gland via hypothalamic- hypophyseal portal veins. Specific hypothalamic hormones bind to receptors on specific anterior pituitary cells, stimulating or inhibiting the release of the hormone they produce (as illustrated in the image on the right).

The following table summarizes the major hormones synthesized and secreted by the hypothalamus and pituitary gland, along with summary statements about their major functions and corresponding regulators.

Hypothalamus

Hormone Released	Hormone Structure	Hormone Function	Hormone Regulator
Hypothalamic Releasing Hormones	Peptides	Acts on the anterior lobe of the pituitary gland to stimulate the release of certain pituitary hormones.	Blood Levels of Specific Substances
Hypothalamic Inhibiting Hormones	Peptides	Acts on the anterior lobe of the pituitary gland to inhibit the release of certain pituitary hormones.	Blood Levels of Specific Substances

Pituitary Gland

	Hormone Released	Hormone Structure	Hormone Function	Hormone Regulator
Anterior Pituitary	Growth Hormone (GH)	Protein	Stimulates muscle and bone growth; Promotes protein synthesis and fat mobilization.	Hypothalamic Hormones
	Prolactin	Protein	Promotes production and secretion of milk in humans after childbirth.	Hypothalamic Hormones
	Thryoid-Stimulating Hormone (TSH)	Glycoprotein	Stimulates production and secretion of thyroid hormones.	Blood Thyroxine Levels; Hypothalamic Hormones
	Adrenocorticotropic Hormone (ACTH)	Polypeptide	Stimulates adrenal cortex to secrete cortisol and other steroids.	Corticotropin-Releasing Hormone (CRH) from the Hypothalamus; Blood Cortisol Levels
Posterior Pituitary	Antidiuretic Hormone	Peptide	Increases water absorption from kidney; Raises blood pressure.	Blood Osmolarity
	Oxytocin	Peptide	Stimulates contraction of pregnant uterus & release of breast milk after childbirth.	Nervous System

As seen in the table above, the anterior pituitary synthesizes and secretes 6 major hormones, among these growth hormone is the most important one to us because it directly regulates our muscle and bone growth.

Physiologic Effects of Growth Hormone

Growth hormone (as illustrated in the image below), also known as somatotropin, is a protein hormone of 191 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary. It is a major participant in control of several complex physiologic processes, including growth and metabolism.

A critical concept in understanding growth hormone activity is that it has two distinct types of effects (as illustrated in the image on the right):

Direct effects are the result of growth hormone binding its receptor on target cells. Fat cells (adipocytes), for example, have growth hormone receptors, and growth hormone stimulates them to break down triglyceride and supresses their ability to take up and accumulate circulating lipids. Indirect effects are mediated primarily by a insulin-like growth factor-1 (IGF-1), a hormone that is secreted from the liver and other tissues in response to growth hormone. A majority of the growth promoting effects of growth hormone is actually due to IGF-1 acting on its target cells.

Keeping this distinction in mind, we can conclude two major roles of growth hormone and its byproduct IGF-1 in physiology:

1. Effects on muscle and bone Growth. Growth is a very complex process, and requires the coordinated action of several hormones. The major role of growth hormone in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. IGF-1 is the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblasts (muscle cells). It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Moreover, IGF-1 stimulates proliferation of chondrocytes (cartilage cells), resulting in bone growth. So Growth hormone has a direct effect on bone growth by stimulating differentiation of chondrocytes.


2. Metabolic Effects. Growth hormone has important effects on protein, lipid and carbohydrate metabolism. In some cases, a direct effect of growth hormone has been clearly demonstrated, in others, IGF-1 is thought to be the critical mediator, and some cases it appears that both direct and indirect effects are at play.

   
   
   • Carbohydrate metabolism: Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range. Growth hormone is often said to have anti-insulin activity, because it suppresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver.
     
   
   
   • Protein metabolism: In general, growth hormone stimulates protein anabolism in many tissues. This effect reflects increased amino acid uptake, increased protein synthesis and decreased oxidation of proteins.
     
   
   
   • Fat metabolism: Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes.
     
   
   

The amount of growth hormone in your blood determines the speed and easiness to convert digested food into energy and utilize it. Therefore, growth hormone is the most crucial substance to keep your weight at a desirable level. Teenagers naturally produce much more growth hormone than middle aged people, so they can still stay fit even they eat lots of food. In the contrast, people who lack growth hormone (older people) will tend to gain weight by just consuming a little food.

The following image is a visual summary of the important points we have covered so far: the relationship between hypothalamus and pituitary gland, as well as the functions of growth hormone and IGF-1.

Negative Feedback Circuit Controls Growth Hormone Secretion.

Production of growth hormone is primarily controlled by a mechanism called Negative Feedback Circuit (although it can also be affected by other factors including stress, exercise, nutrition, and sleep). Feedback circuits are at the root of most control mechanisms in physiology, and are particularly prominent in the endocrine system. Instances of positive feedback certainly occur, but negative feedback is much more common. Negative feedback is seen when the output of a pathway inhibits inputs to the pathway. The heating system in your home is a simple Negative Feedback Circuit. When the furnace produces enough heat to elevate temperature above the set point of the thermostat, the thermostat is triggered and shuts off the furnace (heat is feeding back negatively on the source of heat). When temperature drops back below the set point, negative feedback is gone, and the furnace comes back on. In our case Negative Feedback Circuit is used extensively to regulate secretion of growth hormone. As mentioned above, the release of growth hormone by pituitary gland is actually controlled by hypothalamus. More accurately, two hypothalamic hormones ultimately control all the production of growth hormone:

• Growth hormone-releasing hormone (GHRH) is a peptide that stimulates both the synthesis and secretion of growth hormone. 
  
  
• Somatostatin (SS) is a peptide produced by several tissues in the body, including the hypothalamus. Somatostatin inhibits growth hormone release in response to GHRH and to other stimulatory factors such as low blood glucose concentration.

The Negative Feedback Circuit uses these two hypothalamic hormones to control the secretion of growth hormone.  The basic mechanisms for the negative feedback control in this system (as illustrated in the image on the right) are:

GHRH (Growth Hormone Releasing Hormone) secreting neurons in the hypothalamus detect the low blood concentration of growth hormone and Insulin-like Growth Factor-1 (IGF-1), and in a response these neurons secrete GHRH, which is then carried directly to the anterior pituitary gland via hypothalamic- hypophyseal portal veins. Once arrived at anterior pituitary gland, GHRH stimulates the activities of somatotrophs (cells which secrete growth hormone) so these cells start releasing growth hormone.  Released growth hormone binds to receptors on targeted cells in the body, promoting carbohydrate metabolism, protein synthesis and fat mobilization. Growth hormone also stimulates the liver and other tissues to secrete Insulin-like Growth Factor-1 (IGF-1). IGF-1 in turn acts on its target cells, i.e., chondrocytes (cartilage cells) and myoblasts (precursors of muscle cells) to stimulate muscle and bone growth. Increasing growth hormone level soon negatively feeds back to inhibit GHRH secretion. When blood concentration of growth hormone increases above a certain threshold, GHRH-secreting neurons in the hypothalamus are inhibited and stop secreting GHRH, while SS-secreting neurons in the hypothalamus are stimulated and start secreting SS, which is then carried directly to the anterior pituitary gland via hypothalamic- hypophyseal portal veins. Once arrived at anterior pituitary gland, SS inhibits the activities of somatotrophs (cells which secrete growth hormone) so these cells stop releasing growth hormone. Growth hormone's byproduct - IGF1 also triggers the Negative Feedback Circuit. Increased growth hormone level stimulates liver to secrete IGF-1. High blood levels of IGF-1 not only stimulates the release of SS from the hypothalamus, but also by directly suppresses the somatotrophs in the pituitary gland. The combined effect is the immediate turn-off of growth hormone secretion. As growth hormone levels decay below the threshold, negative feedback is relieved, GHRH secretion starts again, leading to growth hormone secretion... and the circle restarts again.

Integration of all the factors that affect growth hormone synthesis and secretion lead to a pulsatile pattern of release. The natural concentration of growth hormone in blood are very low, because usually the body only secrets growth hormone up to a level to maintain homeostasis and once a steady state is achieved growth hormone secretion is stopped by the Negative Feedback Circuit. Therefore, the only effective way to increase the secretion of growth hormone is to minimize the effect of the Negative Feedback Circuit by creating a natural Positive Feedback Circuit.

The Application of KIMI™ Creates A Natural Positive Feedback Circuit to Stimulate Growth Hormone Secretion.

Positive feedback is seen when the output of a pathway stimulates inputs to the pathway. The gradual increase of Americans' average height in the past three centuries is a good example of a Positive Feedback Circuit. In the 18th century, the average height of the American males was only 5'6'', that of the females was only 5'1''. However, with the rapid development of agriculture and industry in the Untied States, each new generation of Americans enjoyed better food, better health care, and better living condition, thus they increased their average height a little (approximately 1/8 to 1/4 inch) by improving their tall genes a little. When the current generation become parents, they passed these improved tall genes to their children, stimulating a further increase of average height amount the next generation. So the tall genes, under the condition of a constantly improved environment, have become a Positive Feedback Circuit that kept increasing the average height of Americans. Up to now, the average height of both American males and females have been increased by about 3 inches.  

In your case, you need a Positive Feedback Circuit that minimizes the effect of your body's Negative Feedback Circuit and maximizes your pituitary gland's secretion of growth hormone. Here is where our great KIMI™ device comes to serve you: the application of KIMI™ will create a natural Positive Feedback Circuit by stimulating the activities of Adrenal gland, Pancreas, and liver.

KIMI™ actually uses the same principle as the famous Chinese acupuncture, which is called reflexology. Your feet can be seen as mirror images of your whole body. The following picture on the left is a quick look at how the body matches to the sole of the foot. Notice how the shape and curve of the foot matches the shape and curve of the body. The following picture on the right shows that the spinal column is reflected in the inside curve of the foot. Studies have shown that the curve of an individual's foot matches the curve of his/ her spinal column with mathematical precision. Have a look at your own foot and those around you!

Stimulation in any part of your feet mirrors in turn will stimulate the corresponding part of the body. Reflexology is the application of pressure, movement, and stimulation to your feet to affect corresponding parts of your body. Pressure applied to the feet generates a signal through the peripheral nervous system. From there it enters the central nervous system where it is processed in various parts of the brain. It is then relayed to the internal glands and organs to stimulate the necessary adjustments in their activities and functions. 

Before you use KIMI™, you place the most convex parts of the stimulator insoles against the most concave parts of your feet. Referring to the foot reflexology chart above, the nerve points corresponding to your adrenal gland, pancreas, and livers locate at the most concave parts of your feet. When you walk or run with KIMI™, KIMI™ applies the principle of reflexology: the convex parts of the insoles constantly stimulate the nerve points corresponding to your adrenal gland, pancreas, and livers, thus in turn stimulate the activities of these important glands and organ to create a natural Positive Feedback Circuit for the increase of growth hormone secretion. The detailed mechanisms used to create the Positive Feedback Circuit are explained below.

Firstly, the application of KIMI™ stimulates adrenal gland to increase metabolism, while decrease glucose (major form of sugar) and insulin levels in blood. Adrenal gland (as illustrated in the image on the right), which are also called suprarenal glands, are small, triangular glands located on top of both kidneys. An adrenal gland is made of two parts: the outer region is called the adrenal cortex and the center region is called the adrenal medulla. The adrenal cortex produces hormones necessary for fluid and electrolyte (salt) balance in the body such as cortisone and aldosterone, which are not within our concern. However, the adrenal medulla, if under stimulation, produce two very important hormones: epinephrine and norepinephrine, which increase the heart rate and force of heart contractions, facilitates blood flow to the muscles and brain, assists in pulmonary ventilation (better breathing), increase overall metabolism rate, and most importantly,  decrease blood concentrations of glucose and insulin

Insulin (as illustrated in the image on the right) is a small protein containing 51 amino acids. Insulin is secreted by pancreas in response to high blood concentrations of glucose. Glucose (major form of sugar) is liberated from dietary carbohydrate such as starch or sucrose by hydrolysis within the small intestine, and is then absorbed into the blood. High concentrations of glucose in blood stimulate release of insulin, and insulin acts on cells throughout the body to stimulate uptake, utilization and storage of glucose. If the blood concentrations of glucose are low, little or no insulin will be secreted. Thus by stimulating the adrenal gland, the application of KIMI™ increases the overall metabolism and decreases the insulin levels in the blood.

An increased metabolism helps create a Positive Feedback Circuit to increase the secretion of growth hormone because the existing growth hormone in the blood can be quickly carried to its targeted cells and used up to grow muscle and bone. This will decrease the blood concentration of growth hormone and thus trigger neurons in the hypothalamus to secrete GHRH that stimulates pituitary gland into secreting more growth hormone. A decreased blood concentration of insulin also helps create a Positive Feedback Circuit because insulin is the biggest inhibitor for growth hormone's secretion. Recall an important point in the above section of the Negative Feedback Circuit: besides growth hormone itself, its byproduct, Insulin-like Growth Factor-1 (IGF-1) also triggers the Negative Feedback Circuit to inhibit the secretion of growth hormone. Insulin-like Growth Factor-1 (IGF-1), as the name suggests, are structurally very similar to the insulin molecule. Essentially an IGF-1 is about two thirds of an insulin. Since they are almost the same, high blood concentrations of  insulin has essentially the same effect as high blood concentrations of IGF-1 - to inhibit the secretion of growth hormone! Therefore, by decreasing the blood concentrations of both growth hormone and insulin, the application of KIMI™ removes the two main causes that trigger the Negative Feedback Circuit, and starts a Positive Feedback Circuit that leads to increase the secretion of growth hormone.

Secondly, the application of KIMI™ stimulates pancreas to secrete glucagon and further enhances the positive feedback to increase the secretion of growth hormone. The pancreas (as illustrated in the image on the right) houses two distinctly different tissues. The bulk of its mass is exocrine tissue and associated ducts, which produce an alkaline fluid loaded with digestive enzymes which is delivered to the small intestine to facilitate digestion of foodstuffs and has little to do with the secretion of growth hormone. Scattered throughout the exocrine tissue are several hundred thousand clusters of endocrine cells which produce the hormones insulin and glucagon.

Glucagon (as illustrated in the left image below) is a linear peptide of 29 amino acids which has the opposite effect of insulin. That is, glucagon has the effect of increasing blood glucose levels. Knowing that glucagon's major effect is to increase blood glucose levels, it makes sense that glucagon is secreted in response to low blood concentrations of glucose. Although pancreas secretes both insulin and glucagon, it can not secrete both of them at the same time. Exactly which hormone is secreted by pancreas at a certain time is determined by the blood concentrations of glucose. When the blood concentrations of glucose are high, the pancreas secretes insulin; when the blood concentrations of glucose are low, the pancreas secretes glucagon (as illustrated in the right image below). Since the stimulation of adrenal gland has caused low blood concentrations of glucose, pancreas secretes glucagon when it is also stimulated by KIMI™. In contrast to insulin, glucagon is a stimulator for the secretion of growth hormone. Therefore, by stimulating pancreas to secrete more glucagon, the application of KIMI™ further enhances the Positive Feedback Circuit that increases the secretion of growth hormone.

Finally, the application of KIMI™ stimulates liver to secrete IGF-1 in response to the extra growth hormone secreted by the pituitary gland and induce another cycle of the Positive Feedback Circuit. Growth hormone binds to cells in the liver, and these cells release IGF into the blood. Increased metabolic rate and blood circulation resulted from stimulating the adrenal gland carry IGF-1 to its targeted cells and stimulate muscle and bone growth. This in return decreases blood concentration of growth hormone and IGF-1, thus completing a circle of the Positive Feedback Circuit. Then the process returns to step one, where low blood concentration of growth hormone and IGF-1  further trigger another positive feedback and signal hypothalamic to release more GHRH that stimulates pituitary gland to secrete even more growth hormone. The Positive Feedback Circuit will continue like this as long as you keep using KIMI™ to stimulate the activities of adrenal gland, pancreas, and liver. Moreover, such Positive Feedback Circuit is completely natural and safe since the extra growth hormone and IGF-1 are immediately transported to their targeted cells and consumed in stimulating muscle and bone growth. After you stop using KIMI™, the Positive Feedback Circuit is interrupted and your body's Negative Feedback Circuit will soon stop the extra secretion of growth hormone.

Answers to All the Important Questions

After reading all of the above explanations, you should be able to understand the answers to all of the following questions that.

1. What exactly is growth hormone and how does it affect human growth?

Growth hormone, also known as somatotropin, is a protein hormone of 191 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary. Growth hormone facilitates metabolism and controls muscle and bone growth.

2. What exactly is pituitary gland and how does it exactly control the secretion of
   growth hormone?

 
Pituitary gland is a small gland located at the base of the brain. It consists of two different lobes - anterior and posterior pituitary. Its anterior pituitary produces numerous hormones, including the most important growth hormone. Nevertheless, pituitary gland can not be seen as the master gland of the endocrine system, because its activities are directly controlled by a region of the brain called hypothalamus. So strictly speaking, it is not pituitary gland, but hypothalamus which controls the secretion of growth hormone. By detecting the blood concentrations of growth hormone and Insulin-like Growth Factor-1 (IGF-1), hypothalamus secretes Growth Hormone Releasing Hormone (GHRH) or Somatostatin (SS) to stimulate or inhibit pituitary gland's activities of producing growth hormone. The blood concentrations of growth hormone and IGF-1 are in turn regulated by a mechanism called Negative Feedback Circuit in your body: when there is little growth hormone or IGF-1 present in blood, hypothalamus stimulates pituitary gland to secrete some growth hormone; but as soon as the growth hormone level raises a little higher, hypothalamus inhibits pituitary gland to secrete any more growth hormone. In short the pituitary gland only secrets growth hormone up to a level to maintain homeostasis because once a steady state is achieved growth hormone secretion is stopped by the Negative Feedback Circuit. 



3. Why does NOT KIMI™ stimulate the exact nerve points directly correspond to the pituitary gland (the spots under your big toes)? 

 
This should be very clear right now: it is hypothalamus, not pituitary gland that actually controls the secretion of growth hormone, so directly stimulates pituitary gland would have little result on increasing the growth hormone secretion. Moreover, hypothalamus only responds to the blood concentration of the growth hormone and IGF-1, which is strictly regulated by the Negative Feedback Circuit. The only effective way to increase the secretion of growth hormone is to minimize the effect of the Negative Feedback Circuit by creating a natural Positive Feedback Circuit, so the blood concentrations of growth hormone and IGF-1 stay low even when extra amount of growth hormone is secreted by the pituitary gland. As aforementioned, the application of KIMI™ will create such a natural Positive Feedback Circuit by stimulating the activities of adrenal gland, pancreas, and liver. And because the nerve points corresponding to adrenal gland, pancreas, and liver locate at the most concave parts of your feet, KIMI™ stimulates these parts of your feet instead of the spots under your big toes.



4. How exactly does the application of KIMI™ stimulate pituitary gland into producing more growth hormone?

 
The application of KIMI™ stimulates the activities of adrenal gland, pancreas, and liver to create a natural Positive Feedback Circuit, which minimizes the effect of the Negative Feedback Circuit so the blood concentrations of growth hormone and IGF-1 stay low even after pituitary gland secrets extra amount of growth hormone. The constant low blood concentrations of growth hormone and IGF-1 cause hypothalamus to keep secreting Growth Hormone Releasing Hormone (GHRH) which stimulates pituitary gland to keep secreting growth hormone. The Positive Feedback Circuit also increases the metabolism so the extra amount of growth hormone and its byproduct IGF-1 are immediately transported to their targeted cells and used in stimulating muscle and bone growth. For more detailed explanation on how does Kimi work, read the above section named "The Application of Kimi Creates A Natural Positive Feedback Circuit to Stimulate Growth Hormone Secrtion".



5. Why is the application of KIMI™ different from taking any form of artificial growth hormone directly?

 
By now you should understand that the secretion of growth hormone is mainly controlled by the Negative Feedback Circuit, and the only effective way to increase the secretion of growth hormone is to minimize the effect of the Negative Feedback Circuit by creating a natural Positive Feedback Circuit. Taking any form of artificial growth hormone directly can only make the Negative Feedback Circuit in your body much worse. The presence of artificial growth hormone in your blood will immediately trigger the Negative Feedback Circuit to terminate your natural secretion of growth hormone. On the other hand, your metabolism is not increased and can not catch up the quick build-up of artificial growth hormone, so your body can not transport and utilize this "outside" growth hormone effectively. It may quickly end up with large amount of artificial growth hormone accumulating at inappropriate parts of your body and cause all kinds of serious side effects such as negative metabolic effects, hip disease, pancreatitis, and even leukemia (a disease in which the body produces too many white blood cells, causing weakness and sometimes leading to cancer and death). Even worse, if you take artificial growth hormone for a prolonged period, your hypothalamus will become insensitive to blood concentrations and weaken or even lose the ability of stimulating pituitary gland to secrete natural growth hormone even after you stop taking artificial growth hormone. So taking artificial growth hormone is not only futile, but also dangerous. In contrast, the application of KIMI™ is very effective in creating a Positive Feedback Circuit which minimizes the effect of the Negative Feedback Circuit and increases the secretion of your natural growth hormone. The application of KIMI™ also significantly increases your metabolism rate so the extra amount of growth hormone and its byproduct IGF-1 are immediately transported to their targeted cells and used in stimulating your muscle and bone growth. After you stop using KIMI™, the Positive Feedback Circuit is interrupted and your body's Negative Feedback Circuit will soon stop the extra secretion of growth hormone so there will never be any extra growth hormone flowing around in the wrong parts of your body. Such effectiveness and safety measure makes the application of KIMI™ totally different from taking any form of artificial growth hormone directly. 



6. Why is the application of KIMI™ the most natural and effective way to increase your growth hormone level?

 
Similar to the answer to Question 5 above, the application of KIMI™ creates a natural Positive Feedback Circuit to increase the secretion of growth hormone; it also increase your metabolism to transport and utilize extra amount of growth hormone so your body can enjoy the benefits of growth hormone (muscle and bone growth) while avoid any potential danger at the same time. 



7. Why does the application of KIMI™ help you lose fat, gain muscles, grow bigger, stronger, and taller at the same time?

 
So far you must have known that using KIMI™ is the best way to help you increase your growth hormone level effectively and safely. The extra growth hormone induced by the application of KIMI™ has two major physiologic effects: stimulates fat cells (adipocytes) to break down fatty acid (triglyceride) and suppresses their ability to take up and accumulate circulating lipids, as well as stimulates muscle and bone growth. Obviously, the two effects are achieved at the same time: the first effect helps you lose fat and gain muscles, the second effect helps you grow bigger, stronger and taller. Thus the application of KIMI™ helps you lose fat, gain muscles, grow bigger, stronger, and taller at the same time. 



8. Why does the application of KIMI™ bring you dozens of essential health benefits other than helping you lose fat, gain muscles, grow bigger, stronger, and taller?


Besides stimulating adrenal gland, pancreas, and liver, the application of KIMI™ also stimulates stomach colon (large intestine) and small intestine to enable better digestion. As mentioned above, under stimulation adrenal gland secretes epinephrine and norepinephrine, which increase the heart rate and force of heart contractions, facilitates blood flow to the muscles and brain and assists in pulmonary ventilation (better breathing). Thus the application of KIMI™ also helps you prevent heart disease, increase blood circulation, and ensure smoother breathing. Increased blood circulation, breathing, and metabolism in turn reduce tiredness, improve the body's natural curative powers (enhance immune system), promote general good health and retard aging.  In addition, because KIMI™ applies the principle of reflexology, it can bring most of reflexology's benefits as well, such as to reduce stress and induce relaxation, help the body remove toxins and revitalize energy. Therefore, the application of KIMI™ does indeed bring you dozens of essential health benefits other than helping you lose fat, gain muscles, grow bigger, stronger, and taller. And best of all, you can get all of these benefits simultaneously from the application of KIMI™!



9. What are the differences between KIMI™ and all the other fitness/ height increasing programs?
   

KIMI™ is better than all the other fitness/ height increasing programs because it helps you lose fat, gain muscles, grow bigger, stronger, and taller at the same time. Besides being extremely effective and safe, KIMI™ is also very affordable, convenient, and easy for everyone.


10. Why can you benefit from the application of KIMI™ REGARDLESS of your age?
    
There are three strong reasons for you to benefit from the application of KIMI™ regardless of your age. First, the application of KIMI™ will create a natural Positive Feedback Circuit to stimulate your pituitary gland into secreting more growth hormone regardless of your age. It is common knowledge that the levels of both growth hormone and IGF-1 (insulin-like growth factor1) decline dramatically with age. By the time the average person reaches age 60, the pituitary secretes only 25% of the growth hormone than at age 20. However, while it is true that your growth hormone levels may decline with age, your pituitary's capacity to produce growth hormone does not. The pituitary maintains its ability to produce adequate growth hormone well into old age (70 or even older). So why do growth hormone and IGF-1 levels decline? The real reasons are: high glucose and insulin levels, decreased liver function and decreased metabolism rate. As you age, the actives of your adrenal gland and pancreas will decrease so they can not effectively lower blood concentrations of glucose and insulin. High level of glucose and insulin will inhibit the secretion of growth hormone. However, regardless of your age, the application of KIMI™ will directly stimulate the activities of your adrenal gland and pancreas to effectively lower the glucose and insulin level. Moreover, the Positive Feedback Circuit will ensure the blood concentrations of glucose and insulin stay low while you are using KIMI™ to stimulate the secretion of extra growth hormone.  As mentioned above, most of the benefits of growth hormone (such as muscle and bone growth) are due to its byproduct named Insulin-like Growth Factor-1 (IGF-1), not to the growth hormone itself. The liver is the organ responsible for converting growth hormone into IGF-1. As you age, your liver's activity will decrease and only partial conversion of growth hormone into IGF-1 will occur, which will in turn cause large amount of growth hormone stay in your blood and quickly trigger the Negative Feedback Circuit to stop the secretion of growth hormone. However, regardless of your age, the application of KIMI™ will directly stimulate the activity of your liver to convert growth hormone to IGF-1 and complete the Positive Feedback Circuit as described above. As you age, your metabolism rate will slow down. Fast metabolism rate is necessary to transport growth hormone and IGF-1 to their targeted cells and utilize them to grow muscle and bone. A slow metabolism could cause growth hormone and IGF-1 to idle around in your blood and quickly trigger the Negative Feedback Circuit. However, regardless of your age, the application of Kimi will dramatically increase your metabolism rate to facilitate the transportation and utilization of growth home and IGF-1. Therefore, no matter how old you are, the application of Kimi will create a natural Positive Feedback Circuit to stimulate your pituitary gland into secreting more growth hormone.

Second, our years' painstaking research shows that it is possible for people who are over 25 to grow a few inches taller (you can grow even more if you are younger than 25). One, your spinal column can be extended by another 1 or 2 inches by using KIMI™. Two, even after your bones are fused, extra growth hormone and fast metabolism can still make your bones grow thicker and stronger. The added thickness alone can increase your height by half to one inch. Three, although most of your bones can't grow any longer, the cartilage that connect many bones in your body can still grow thicker. Besides the discal portion on each of your vertebrae, the distal end of your Femur (bottom of you thigh bone at the knee) and the proximal end of your Tibia (top part of your shin bone at the knee) each can grow up to an inch, which gives you another 2 inches extra height. 

Third, although KIMI™ is specially designed to help people lose fat, gain muscles, grow bigger, stronger, and taller, the application of KIMI™ will give you so many other essential health benefits and improve your overall mental and physical conditions (please refer the answer to question #8 above for the details on all the essential health benefits of KIMI™). Also, if you order by the deadline shown on our web site, you will receive 40 fantastic free bonuses ($299 value), including the best diet, sleeping habit, other exercises, and many other inside secrets about human growth. In short, you are definitely going to benefit in many ways by using KIMI™ regardless of your age. So there is absolutely no reason or excuse not to give it a try (especially after we give away lifetime double money back guarantee).

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